I currently use Hilton but I think all the big name chains are about the same so as long as you pick one and stick with it you will be fine.
I picked Hilton because they always have at least one in most cities and Hilton has a huge cleaning protocol.
If your interested apply for the Hilton Honors Card - Right now your looking at a $100 statement credit and 100,000 points for spending $1,000 in 3 months. Pretty doable in most families then you can use the $100 credit for a few Six Flags passes and have a hotel when you get there.
Thanks for using the links - it helps support the site and Podcast